Stillingstittel:
PhD position at the Department of Chemistry - Marie Sklodowska-Curie ITN-ETN. PhD position (ESR9) P

Stillingsbeskrivelse:

The University of Bergen (UiB) is an internationally recognised research university with more than 14,000 students and close to 3,500 employees at six faculties. The university is located in the heart of Bergen. Our main contribution to society is excellent basic research and education across a wide range of disciplines.

Jobbnorge ID: 126426

At the Department of Chemistry (www.uib.no/en/kj) there is a vacancy for a PhD position in synthetic organic chemistry / medical technology. The position is for a fixed term of 3 years and will be associated to the Marie Curie ETN project PET Imaging in Drug Design and Development (PET3D), http://www.abdn.ac.uk/pet3d

 

About the "PET Imaging in Drug Design and Development (PET3D)" programme

Contemporary drug development is rather inefficient and difficult to sustain. To keep drug development affordable, it should become more efficient and rationalized. Molecular imaging can play a pivotal role in changing the landscape of drug design and development and improving the health care system. Positron Emission Tomography (PET) imaging, in particular, is the technology that has the potential to lead this fundamental innovation by providing at a much earlier stage reliable answers to key questions emerging during the care cycle: what and where is the disease? Is the disease accurately targeted by the therapy? Is the treatment effective? By answering the questions above, PET imaging has the capacity to render much more effectively the transition from pre-clinical to clinical phase, and to strongly facilitate the development of better drugs at an earlier stage and in a much more sustainable manner. However, new radiolabelled compounds, so-called tracers, are required to be able to use PET successfully.

 

The Bergen section of the PET3D consortium shall design, develop and optimize new synthetic methods necessary for the synthesis of new tracers targeting hypoxic tumour tissue, NTR-bioreductive probes, and/or targeted drug delivery. To achieve that we will synthesize and characterize highly functionalized radiolabeled (¹⁸F or ¹¹C) 2- and 4-nitroimidazoles and/or other biologically relevant compounds. The novel scaffolds will be investigated as radiotracers at the pre-clinical PET/CT-scanner at Haukeland University Hospital

 

Job description - Early Stage Researcher 9 (ESR9)

The main tasks for the PhD research fellowship (ESR9) will be as follows:

• Design, devlopment, and optimization of synthesis leading to novel precursors for PET tracers
• Development of methodology for continuous flow synthesis
• Development of novel synthetic methodology necessary for the PET precursor synthesis
• Development of radiolabeling methods (¹⁸F, ¹¹C)
• Radiosynthesis of new tracers
• In collaboration with dedicated personnel conduct evaluation in-vitro and in-vivo studies of new PET tracers

ESR9 will be expected to publish results in international peer-reviewed journals, present results at international symposia and to complete a PhD thesis.

 

Qualifications, personal qualities, and eligibility criteria

• Applicants must hold a master's degree or the equivalent in chemistry with specialization in organic synthesis, or must have submitted his/her master's thesis for assessment prior to the application deadline. It is a condition of employment that the master's degree has been awarded
• Candidates should have a strong background in synthetic organic chemistry. Knowledge/experience in heterocyclic chemistry, transition metal catalyzed reactions applicable in organic synthesis, knowled
  
  Minstelønn: 0
  
  Maksimal lønn: 0
  
  Arbeidsgiver Navn: Universitetet i Bergen
  
  Arbeidsgiver adresse: Allegaten 41 5020 BERGEN
  
  Job kort beskrivelse: University and higher education teachers
  
  Land: Norge
  
  Region: Hordaland
  
  Kilde til jobbtilbud: NAV, Offentlige arbeidsformidlinger, Norge
  
  Lønn valuta: NOK
  
  Lønn periode: Pr. år
  
  
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