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Stillingstittel: Researcher in Mucosal Immunology

Stillingsbeskrivelse:
Jobbnorge ID: 164787

Job abstractJV_description

A two year and two month position as a researcher (SKO 1109) is available at The Institute of Clinical Medicine, Division of Laboratory Medicine, Department of Pathology.  

More about the position

The candidate will be participating in the study of plasma cell biology in the human gut in Professor Frode Jahnsen's laboratory, at the University of Oslo. The project will be performed in close collaboration with the Department of Public Health and Primary Care (DPHPC), University of Cambridge.

The Mucosal Immunology group at the UiO has been part of a world-leading center in immunology for the past 10 years and is currently part of FOCIS Centre of Excellence. The group collaborates intimately with surgeons and gastroenterologists at Oslo University Hospital and has unique access to human clinical material (see Landsverk et al, JEM 2017,Bujko et al, JEM 2018 and Richter et al. Mucosal Immunol. 2018). The group studies human mucosal immunology in health and in disease conditions, such as inflammatory bowel disease, graft-versus-host disease in allo-hematopoietic stem cell transplanted patients and colorectal cancer. For more information please follow the link.

 

The project recently demonstrated that plasma cells in the human intestine can persist for decades. This represents a paradigm shift in our understanding of humoral immune memory in the gut (Landsverk et al JEM 2017). By directly building on this information this project aims to identify molecular mechanisms underlying the selection of long-lived intestinal plasma cells and to explore the cross-talk between gut plasma cells and the microbiota. This part of the project will focus on functional characterization of gut-derived plasma cells including their interaction and regulatory effect on the gut microbiota, B cell receptor repertoire analysis, and interactions with intestinal stromal cells.

The researcher will be working at the University of Oslo and collaborate closely with a postdoc in Systems Biology at the University of Cambridge. The successful candidate will work under supervision of Frode Jahnsen (UiO), Ole Landsverk (UiO) and Michael Inouye (PHPC).  More information about Professor Inouye can be found at this site. 

Qualification requirements

• Interested candidates must have obtained a Ph.D. in immunology or related subjects, with a strong background in immunology. Prior knowledge of plasma cells and antibodies is highly desirable.  
• Experience working with B cells/ plasma cells in vivo and in vitro
• Experience with B cell receptor analysis
• Experience with flow cytometry and confocal microscopy
• Experience with cell sorting from biological samples
• Experience with dissection and tissue processing
• High level report writing and presentational skills
• Experience with CYTOF
• Experience working with bacteria/microbiota
• Experience of statistical method development

Personal skills

• We are looking for a talented and highly motivated researcher
• The candidate should be highly motivated and dedicated, proficient in written and spoken English
• Good team working skills are required

We offer

• Salary NOK 515 200 - 597 400 per annum depending on qualifications in position as Researcher (position code 1109).
• A professionally stimulating working environment
• attractive welfare benefits and a generous pension agreement, in addition to Oslo's family-friendly environment with its rich opportunities for culture and outdoor activities

How to apply

The application must include

• Cover letter (statement of motivation, summarizing scientific work and research interest)
• CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
• Copies of educational certificates (academic transcripts only)
• A complete list of publications
• List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)

The application with attachments must be delivered in our electronic recruiting system Jobbnorge. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).

In assessing the applications, special emphasis will be placed on the documented, academic qualifications, the project abstractJV_description (whenever this is required in the call for applicants), and the quality of the project as well as the candidate's motivation and personal suitability. Interviews with the best qualified candidates will be arranged.

It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Formal regulations

According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

The University of Oslo aims to achieve a balanced gender composition in the workforce and to recruit people with ethnic minority backgrounds.

Contact information

• Professor F. Jahnsen, e-mail: f.l.jahnsen (at) medisin.uio.no
• HR adviser Karoline Berg-Eriksen (questions regarding the online application form), e-mail: Karoline.berg-eriksen (at) medisin.uio.no

Se annonsen og søk på stillingen www.jobbnorge.no

numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2212

abstractJV_contact_0: See jobabstractJV_description

Arbeidsgiver Navn: Universitetet i Oslo

source: NAV