Stillingstittel: Postdoctoral Fellows

Stillingsbeskrivelse:
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.2 Postdoctoral Fellows at Department of Microbiology - Oslo Universitetssykehus HF

2 postdoctoral positions are available at our department. They will commence as soon as possible and will extend over a minimum of 3 years with an evaluation period of 3 months. A selection committee will announce the candidates two weeks after the closing deadline for interviews. This post will focus on characterizing novel mechanisms for gene regulation and the identification of underlying genes and enzymes. Relevant methods include Chip-Seq, PAR-CLIP, RIP-seq, RNA-seq in various model cellular systems as well as transgenic mice models.

Job description

• The project is about the mechanisms of dynamic histone and RNA plasticity in mouse and human cells. With recent pioneering work, the field of RNA regulation in pluripotency, reprogramming and lineage choice is rapidly gaining momentum.

Qualifications

• Potential candidates have completed (or are close to completing) a PhD degree in molecular biology or medicine, with one or several publications in internationally well-regarded, peer-reviewed scientific journals.
• Knowledge of basic methods in molecular biology (cloning) and tissue culture is essential. Also required is experience with at least one of the following research areas: Histone modifications, RNA biochemistry methods (including PAR-CLIP, RIP-seq, and RNA-seq), microRNA biology, knock-down/overexpression systems, Crispr-Cas9 based engineering. Experience with live cell imaging and R/Matlab based tools is advantageous.
• Relevant References:
• Ke, Alemu, Mertens et al A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015:29:2037-53
• Filipczyk A, Marr C, Hastreiter S, Feigelman J, Schwarzfischer M, Hoppe PS, Loeffler D, Kokkaliaris KD, Endele M, Schauberger B, Hilsenbeck O, Skylaki S, Hasenauer J, Anastassiadis K, Theis FJ, Schroeder T. Network Plasticity of Pluripotency Transcription Factors in Embryonic Stem Cells. Nature Cell Biology, 2015:17:1235-46.
• Filipczyk A, Gkatzis K, Fu J, Hoppe PS, Lickert H, Anastassiadis K, Schroeder T. Biallelic expression of Nanog protein in mouse embryonic stem cells. Cell Stem Cell, 2013:13:12-3.
• Zheng, Dahl, Niu et al ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013:49:18-29.
• Applicants with publications in press are also considered. Interested persons should submit the following documents (note that applications lacking any of these three requirements will be terminated without further evaluation):
• 1) A concise application letter explaining your motivation for this position (1-2 pages).
• 2) Curriculum vitae including a list of peer-reviewed publications.
• 3) Contact information of three references.

Education field

• Biomedical Laboratory Sciences
• Biology

Education level

• College / University, Doctorate

Personal qualities

• We are looking for enthusiastic and determined individuals who can work both independently as well as in a group setting.


Minstelønn: 0

Maksimal lønn: 0

Arbeidsgiver Navn: Oslo Universitetssykehus HF

Arbeidsgiver adresse: 0372 OSLO

Job kort beskrivelse:
Biologists, botanists, zoologists and related professionals

Land: Norge

Region: Oslo

Kilde til jobbtilbud: NAV, Offentlige arbeidsformidlinger, Norge

Hvordan søke: Annet - se fritekst

Lønn valuta: NOK

Lønn periode: Pr. år


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