Stillingstittel:
Post-doctoral fellowship: Drug Synergy Analysis in Precision Hematology

Stillingsbeskrivelse:
The University of Oslo is Norway’s largest institution of research and education with 28 000 students and 7000 employees. Its broad range of academic disciplines and internationally esteemed research communities make UiO an important contributor to society.

We seek a postdoc to work in the field of precision medicine in hematology, analyzing and modeling cancer drug sensitivity screening (CDSS) data. The project is funded by the Faculty of Mathematics and Natural Sciences under their innovation programme and will be linked to the Digital Life Norway national centre for computational biology. The postdoc will add to a very active research group at Centre for Molecular Medicine Norway (NCMM) / Biotechnology Centre in close collaboration with the Oslo Centre for Biostatistics and Epidemiology (OCBE).

Project: Together with the clinical collaborators in hematology and oncology the Tasken group has started a cluster of projects on different cancers where we aim to individually tailoring new treatments for leukemia and other cancers. The project will establish a pipeline to identify drugs and drug combinations effective in personalized therapy of individual patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), for whom other treatment options are exhausted or ineffective. The research focuses on the pathogenesis of CLL and myeloma in patients and will identify pathway aberrations amenable for drug targeting in a personalized medicine context. Work will involve the development of new statistics and machine learning methodology for data-driven analyses and modeling of cancer signal networks, particularly focusing on drug synergy prediction.

At the moment we are jointly searching for a postdoctoral researcher for the above project as follows:

Post-doctoral research fellow – Drug Synergy Analysis in Precision Hematology The successful candidate will work with development of novel statistical, machine learning and bioinformatics methods and algorithms to integrate complex multi-layered big-omics and molecular data; to identify latent signals with the predictive power for tailoring patient treatment. This will be followed by in-depth analysis of primary patient samples in hematological cancer, which collates and profiles their multi-layered –omics data and developing routines, informed by the scientific pipelines and predictive models, for systematic analysis of data from CDSS of primary patient samples for synergy.

Post-doctoral candidate:

We seek a highly motivated individual holding a strong PhD degree that appreciates working in an international and interactive environment. The completed PhD degree is in statistics, machine learning, computational sciences or equivalent science. We are looking for highly motivated candidates with an outstanding potential and a strong statistical or/and machine learning background. Proven experience in advanced programming is required. Experience in chemical biology, CDSS or drug synergy analysis would be a benefit as will good understanding of chemical biology, cancer biology, and hematology, but these are not necessary competences. The ideal candidate has specific interest in working in a collaborative translational research project, in cancer cell signaling, chemical biology and CDSS.

University of Oslo has an agreement for all employees, aiming to secure rights to research results and intellectual property.

The postdoctoral-position will be placed as SKO 1352 post-doctoral research fellow, with salary range depending on qualifications: step 57 - 65 (NOK 483 700 – 560 700). The position is for four years including 25% time for innovation-related activities.

Background:

The Centre for Molecular Medicine Norway (NCMM, www.ncmm.uio.no) was established in 2008 as a national partnership institution with the European Molecular Biology Laborator

Minstelønn: 0

Maksimal lønn: 0

Arbeidsgiver Navn: Universitetet i Oslo, Biotechnology Cent

Arbeidsgiver adresse: 0313 OSLO

Job kort beskrivelse: University and higher education teachers

Land: Norge

Region: Oslo

Kilde til jobbtilbud: NAV, Offentlige arbeidsformidlinger, Norge

Lønn valuta: NOK

Lønn periode: Pr. år