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reference: 03131908000130

documentId: 03131908000130

connectionPointId: 261

Stillingstittel: Researcher

Stillingsbeskrivelse:

Org. nr: 998157617 Stillingsident: 4102338701 Presentasjon av stillingen:

A permanent position as researcher is available at Dept. of Medical Genetics, Section for Research and Development.

Medical genetics is an exciting field in rapid development with the introduction of new groundbreaking technologies for the examination of patients' genes as the basis for personalized medicine, also known as precision medicine. The department is a key player in the Norwegian health service and leads the national research infrastructure "Norwegian Consortium for Sequencing and Personalized Medicine" (www.norseq.org). The department's researchers collaborate with research environments in the hospital / university as well as at other institutions nationally and internationally.

The Department of Medical Genetics at Oslo University Hospital (OUS) consists of Section for Clinical Genetics, Section for Hereditary Cancer, Section for Laboratory Diagnostics, Section for Quality and Section for Research and Development. The research and development section (about 50 people) consists of 10 researchers, 25 post-doc and PhD students, as well as students and technical staff. We can offer work in a modern and enthusiastic research environment.

Job abstractJV_description and requirements

The candidate will:

• be an independent researcher within an existing research group at the Department.
• develop innovative omics methods to study primary and metastatic cancer with systems biology approaches.
• develop bioinformatics- and statistical analysis of high dimensional and next generation sequencing (NGS)-omics data.
• supervise students at MSc and PhD Level.
• acquire competitive research funding.

Qualifications/Educations

The candidate:

• holds a PhD in biomedicine, molecular biology, biochemistry or in another relevant field.
• have experience equivalent to two postdoc periods supported by relevant publications.
• should have a research profile that will strengthen the Department's research within molecular mechanisms of the most common diseases.
• Potential for synergies between ongoing research in the Departments and between basic, translational and clinical research in the Hospital is a requirement.
• Her/his expertise shall be in developing innovative -omic methods to study primary and metastatic cancer with systems biology approaches.
• A strong background in wet lab to prepare and analyze biopsies in bulk and at the single cell level is necessary.
• Experience in modelling human diseases using cell line, organoids and iPSC models for functional studies is also expected.
• A deep understanding of bioinformatics and statistical analysis of high dimensional and next generation sequencing (NGS)-omics data is required.

Molecular and cellular biology skills

• Cell culture including organoid culture, transfection and derivation of iPSC cells from fibroblast and blood cells.
• Mapping transcription factors binding regions using ChIP-seq.
• Mapping regulatory elements such as enhancers using Gro-seq and/or CAGE-seq.
• Preparation of primary tumor samples for single cell RNA sequencing.
• Library preparation and sequencing.
• DNA methylation analysis (pyrosequencing, EPIC array).
• DNA hydroxymethylation analysis (oxBS-seq, RRHP).
• Immune cell purification, flow cytometry and sorting.
• Purification and immunoprecipitation of membrane proteins.

Computer science skills

• Extensive knowledge of python and R.
• Integrating the same type of omics data across different studies.
• Integrating different types of omics data for the same cohort.
• Machine learning approaches for image and data analysis, for imputation and for biomarker discovery.
• Dimension reduction, clustering and differential expression analysis of single cell RNA-seq data.
• Deconvolution algorithm to infer intra tumor heterogeneity.
• Somatic, germline SNP imputation and analysis with eQTL.
• Analysis of next generation sequencing data: RNA-seq, ChIP-seq, CAGE-seq, etc.

Personal qualifications

• The ability to create an attractive research environment will be emphasized.
• Contribute to an innovative and interdisciplinary research environment.
• Individual suitability is emphasized.
• A good command of English is required.
• A good understanding of Norwegian is an advantage.

We offer

• Salary in accordance with experience.
• High professional level.
• Professional and personal development.
• Flexible hours.
• New technology.
• International academic research environment
• A workplace that is an inclusive working life (IA) Company.
• Membership in pension scheme, 2% pension enabstractJV_titlements, group and accident insurance and leisure accident Insurance.

Please send your application, CV and publication list.
Only applications via webcruiter will be considered.

Kontaktinformasjon

Vesslea Kristensen, Professor, +47 22 78 13 75, v.n.kristensen (at) medisin.uio.no
Line Mygland, Forskningskoordinator, +47 23 01 67 73, linmyg (at) ous-hf.no

Arbeidssted

AMG, Ullevål sykehus, Kirkeveien 166
0450 Oslo

Søk på stillingen:Klikk her

Nøkkelinformasjon:

Arbeidsgiver:Oslo universitetssykehus HF

Referansenr.:4102338701
Stillingsprosent: 100%
Startdato: 01.10.2019
Søknadsfrist: 15.09.2019

PAM

numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2131

abstractJV_contact_0: See jobabstractJV_description

contractTypeCodes_0: fulltime

Arbeidsgiver Navn: Sykehuspartner

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