id: MDMzNTE5MDUwMDAyNTUgMjYx

reference: 03351905000255

documentId: 03351905000255

connectionPointId: 261

Stillingstittel: Research technician in cancer immunotherapy

Stillingsbeskrivelse:

A full-time position as research technician in cancer immunotherapy is available for 2 years from June 15th 2019, in the project group of Dr. Jon Amund Kyte at Dept. of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital (OUS) Radiumhospitalet. OUS is Norway-s largest hospital and medical research institution, and is accredited as Comprehensive Cancer Center by the Organisation of European Cancer Institutes. OUS Radiumhospitalet is a dedicated cancer center with a particularly strong research profile in cancer immunotherapy. We have a proven record in bringing novel immunotherapy ideas from preclinical development into clinical studies.

Job abstractJV_description

We are seeking a highly skilled and motivated research technician for working on two projects:

Development of chimeric antigen receptors (CARs) for adoptive T cell therapy targeting solid tumors. CAR T cell therapy has shown remarkable efficacy against hematological malignancies. The project aims to bring CAR T cell therapy to solid cancers, by exploring novel strategies for CAR design, targeting unexplored tumor antigens and countering key mechanisms for tumor tolerance. The technician will work with postdoc-s in the group and perform molecular cloning of novel CAR constructs, testing of CAR T cell functionality in immune assays and animal models. A variety of advanced cellular/molecular immunology technologies will be used, as well as methods for response and toxicity assessments in animal models. Development of novel cancer therapy combining PD-1 and CTLA-4 blockade with immunogenic chemotherapy or radiotherapy. We (PI JA Kyte) have started three clinical trials, enrolling a total of 170 patients, investigating PD-1/CTLA-4 blockade combined with immunogenic chemotherapy or radiotherapy. The trials pioneer the strategy of combining chemo/radio-therapy known to induce immunological cell death with immune checkpoint blockade. We collect biopsies, peripheral blood cells and other samples from the trial patients. The technician will contribute to biobanking and perform translational research on material from trial patients, aimed at identifying biomarkers of response and uncovering tumor/immune evolution during therapy. A variety of advanced cellular/molecular immunology technologies will be used.

The technician will work in team with other members of the Kyte project group, at the Department of Cancer Immunology. The Kyte group has 9 members with research background in immunology and medicine and is affiliated with the group of professor Malmberg, which comprises about 25 research members. Dr. Kyte is Head of the Department for Experimental Cancer Treatment and project group leader at Dept. of Cancer Immunology.

Qualifications

• We are looking for a candidate that is highly motivated and with a research background in immunology, including animal models.
• Great emphasis will be placed on personal aptitude and on the ability to collaborate.
• The candidate must have experience in immunology and animal models, as well as excellent written and oral communication skills (English).
• The ideal candidate will have experience in T cell immunology with robust practical skills in molecular and cellular biology, including animal studies, cell culture, mRNA work, retroviral transduction, flow cytometry and T-cell functional assays.
• Knowledge in CAR or TCR research will be an important asset.

The application must include

• The application letter (including a summary of applicant-s scientific work and interest and describing how she/he fits the abstractJV_description of the person we seek)
• CV (summarizing education, positions and other qualifying activity)
• Copies of educational certificates with grades, letters of recommendation
• Names, email and telephone number of 3 referees (describe relation to applicant)
• A complete list of publications

The Application must be submitted through Webcruiter.

We offer

• Interesting and challenging research projects with huge potential for clinical application
• A productive and motivating research environment
• Full-time two-year position
• Salary according to the OUS salary scale
• Favorable pension arrangements
• Attractive welfare arrangements

Kontaktinformasjon

Jon Amund Kyte , , M.D. PhD, (+47) 22 93 47 38, jon.amund.kyte (at) ous-hf.no

Arbeidssted

Ullernchausseen 70
0379 Oslo

Søk på stillingen:Klikk her

Nøkkelinformasjon:

Arbeidsgiver:Oslo universitetssykehus HF

Referansenr.:4083302390
Stillingsprosent: 100%
Søknadsfrist: 03/06/2019

PAM

numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C3116

abstractJV_contact_0: See jobabstractJV_description

contractTypeCodes_0: fulltime

Arbeidsgiver Navn: OSLO UNIVERSITETSSYKEHUS HF

source: NAV