Stillingstittel:
Postdoctoral Research Fellowship in Cell Biology/Cellular Immunology/intracellular trafficking (2015/13501)

Stillingsbeskrivelse:
The University of Oslo is Norway’s largest institution of research and education with 28 000 students and 7000 employees. Its broad range of academic disciplines and internationally esteemed research communities make UiO an important contributor to society.

Position as Postdoctoral Research Fellow is available at Department of Biosciences, Faculty of Mathematics and Natural Sciences.

The position is for initially for two years, but prolongation is possible. Within the framework of the position, duties may be assigned. In regards to the post doctoral position, no one can be appointed for more than one fixed-term period at the same institution.

Job description/Project description:

The project focuses primarily on unraveling the function of the endocytic pathway toward antigen loading using biophysical techniques, molecular biological techniques, biochemistry, imaging (e.g. live imaging) and molecular/imaging/biochemical screens in cell culture systems and cells from knock out/knock in mice. The project will focus on unraveling the pathway towards MHC II antigen loading, in particular for the molecules that associate with the transport to and from this compartment in immune cells, both in cell lines and in human dendritic cells (See e.g. Neefjes et al., 2011, Nature immunology and publications by the supervisors (Medline, in particular Oddmund Bakke and Jacques Neefjes). We also work, together with a clinical group at the University Hospital, and we have patented a vaccine for immunotherapy by improving loading of the MHC molecules, both MHC class I and class II. The Bakke group is a member of a CoE, Centre for Immune Regulation and prof Oddmund Bakke is also the head of the National imaging platform NorMIC Oslo, with a wide range of imaging equipment, including equipment at the Oslo University hospital, a node headed by prof Harald Stenmark. The centre is a part of ESFRIs EurobioImaging Network. The work will include collaboration with national and international groups in particular Prof. Jacques Neefjes at the Dutch Cancer Centre, NKI in Amsterdam and with the Preben Morth Group who is a part of the Centre for Molecular Medicine Norway.This position is one of two positions in this field, please see here for more information about the researcher position connected to this.

Qualifications:

The Faculty of Mathematics and Natural Sciences has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.

The candidates must have a PhD or other corresponding education equivalent to a Norwegian doctoral degree in molecular biology, cell biology, biophysics or biochemistry.We are seeking highly motivated and skilled researchers with broad and extensive experience within one or more of the following areas: advanced imaging, molecular biology, cellular immunology, cell biology, biochemistry, and protein chemistry.

Prior experience with intracellular membrane/protein traffic, advanced cellular imaging, membrane/organelle biogenesis will be considered a strong advantage.

The main purpose of post-doctoral research fellowships is to qualify researchers for work in top academic positions within their disciplines.

Please also refer to the regulations pertaining to the conditions of employment for post-doctoral fellowship positions: