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documentId: 03311902000284

connectionPointId: 261

Stillingstittel:
PhD Research fellowship in chemistry for medicine (immunology)

Stillingsbeskrivelse:
Job abstractJV_description

A three-year full time PhD Research fellowship (position code 1017) in chemistry and engineering in medicine is available at Department of Immunology, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo.

More about the position

One year of the fellowship will be spent a Stanford ChEM-H Institute, Stanford University. The fellowship is funded by University of Oslo's program on World Leading Research Communities  and is integrated in an international partnership (INTPART) project funded by the Research Council of Norway.

The project will be undertaken in the research group of Professor Ludvig M. Sollid (University of Oslo) and Professor Chaitan Khosla (Stanford University) focusing on the role of transglutaminase 2 (TG2) in the pathogenesis of celiac disease. The successful applicant will join active research groups at the University of Oslo and at Stanford University. In Oslo, the student will be part of KG Jebsen Centre for Coeliac Disease Research, a translational medicine center.

The candidate will undertake a project that studies the structure, function, and regulation of the enzyme Transglutaminase 2 (TG2) in celiac disease. Celiac disease is a common disease caused by acquired immune reactions to cereal gluten proteins. TG2 is involved in the pathogenesis of celiac disease by its ability to post-translationally modify gluten peptides so that they become recognized by disease-driving, gluten-specific CD4+ T cells, and by being the target of an IgA auto-antibody response. Inhibition of TG2 enzymatic activity is an attractive therapeutic target, but the biology of TG2 remains poorly understood.

The candidate will work aspects of TG2 biology that are crucial to develop targeted therapy:

• characterize binding partners of TG2 in the extracellular milieu
• address whether redox-regulation of extracellular TG2 activity is influenced by protein-protein interactions
• probe for TG2 activity in vivo in mice by use of chemical reporter molecules.

The candidate will work with methods such as biochemical assays with recombinant proteins, mass spectrometry based protein analysis of isolated proteins or tissues and chemical engineering in relation to TG2 detection or inhibition.      

The research fellow must take part in the PhD program of the Medical faculty at the University of Oslo and is expected to complete the project and to follow the PhD program at the Medical faculty in order to obtain a PhD. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.

The applicant must, in collaboration with her/his supervisors, within 3 months after employment, have worked out a complete project abstractJV_description to be attached to the application for admission to the doctoral program. For more information, please see our web site.

Qualification requirements

• Applicants must hold a Master's degree in chemistry, biochemistry, molecular biology, biochemical engineering or a related field. 
• Minimum 1 year of research experience in a biochemical or chemical research laboratory
• Authorship of publication(s) in a major peer-reviewed journal is considered an advantage
• Experience with advanced mass spectrometric methods is considered an advantage.
• The candidate will work in an ambitious interdisciplinary setting which will require high flexibility.
• Fluent oral and written communication skills in English.

We offer

• Exciting research environments across institutions with strong opportunities for academic development.
• Pay Grade 51-57, from NOK 449 400 to NOK 497 000, depending on qualifications in a position as PhD Research fellow (position code 1017).
• Tuition paid at Stanford University for one year.
• Financial support for stay in the US according to rates of the Research Council of Norway.
• Attractive welfare benefits and a generous pension agreement, in addition to Oslo's family-friendly environment with its rich opportunities for culture and outdoor activities.

How to apply

The application must include:

• Application letter describing the applicant's qualifications and motivation for the position
• CV (summarizing education, positions and academic work - scientific publications)
• A complete list of publications
• Master's thesis
• Copies of educational certificates, transcript of records
• List of publications and academic work that the applicant wishes to be considered by the evaluation committee
• Letters of recommendation or names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number)

The application with attachments must be delivered in our electronic recruiting system, please follow the links "apply for this job". Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).

Applicants, who are invited for an interview, are asked to provide educational certificates, diploma or transcript of records.

Formal regulations

Please also refer to the regulations pertaining to the conditions of employment for research fellowship positions

Information about guidelines concerning appointment to post doctoral and research posts at UiO

No student can be appointed for more than one PhD Research Fellowship period at the University of Oslo.

In accordance with the University of Oslo's equal opportunities policy, we invite applications from all interested individuals regardless of gender or ethnicity.

The University of Oslo has an Acquisition of Rights Agreement for all employees for the purpose of securing intellectual property rights to research results, etc.

Pursuant to section 25, subsection 2, of the Freedom of Information Act, information concerning the applicant may be disclosed to the public, even if the applicant has requested not to appear on the list of applicants.

Contact information

• Professor Ludvig M. Sollid, e-mail: ludvig.sollid (at) medisin.uio.no
• Researcher Jorunn Stamnæs, e-mail: jorunn.stamnas (at) medisin.uio.no
• Professor Chaitan Khosla, e-mail: khosla (at) stanford.edu
• HR-adviser Karoline Berg-Eriksen, (questions regarding the online application form), e-mail: Karoline.berg-eriksen (at) medisin.uio.no

Se annonsen og søk på stillingen www.jobbnorge.no

numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

abstractJV_contact_0: See jobabstractJV_description

Arbeidsgiver Navn: Universitetet i Oslo

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