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Stillingstittel:
Do you want to be a PhD student in a world-leading environment at Oslo University Hospital Rikshospitalet?

Stillingsbeskrivelse:

PhD Fellowship at the Norwegian PSC Research Center  

The Norwegian PSC Research Center (NoPSC) at the Oslo University Hospital (OUH) and the University of Oslo (UiO) is dedicated to research on the chronic liver disease primary sclerosing cholangitis (PSC). Several features make PSC an intriguing model disease; more than 80% of the patients have inflammatory bowel disease, for which the link with the biliary inflammation is poorly known. Furthermore, as much as 15-20% of the patients develop cancer of the bile ducts, for which also the cause is unknown.
The center comprises three research groups covering all aspects of research related to primary sclerosing cholangitis, from basic genomic and experimental studies to clinical research and clinical trials. The research environment is world-leading for PSC and counts 10-15 engaged researchers from several countries and specialities.   
We have now a vacant position as a PhD fellow (3 years).

We are seeking a motivated and meticulous co-worker to take on a challenging Project; "Effects of microbiota and immune priming in a murine model of bile duct inflammation" related to microbiota effects on the immunological and biliary tract phenotype in germfree and gnotobiotic mouse models. In addition to the mouse models, the candidate will work with relevant immunological in vitro systems. With these approaches we aim to elucidate microbiota regulation of immune system maturation and mechanistic effects on bile duct inflammation. The group for experimental liver research, led by Espen Melum, has together with international collaborators, established a unique set of tools and mouse models for querying key mechanisms for immune regulation in the bile ducts. These capabilities include infrastructure for experimental use of germfree and gnotobiotic mouse models, established in collaboration with the Head of Comparative Medicine at Oslo University Hospital, ass prof. Henrik Rasmussen. The position represents a unique opportunity for a hard-working candidate. The successful candidate must hold an MD degree or a masters degree in comparable biological sciences (or foreign equivalent degrees). The main supervisor for the PhD student will be Henrik Rasmussen.

     
Arbeidsoppgaver

Perform required animal experiments, data analysis and interpretation, according to project plans

Publish project results and defend PhD thesis

Completion of UiO PhD program courses, including lab animal course

Kvalifikasjoner

MD or a masters degree in a comparable biological science

Experience with microbiology, microbial ecology, immunology and/or experimental animal work is an advantage

Flexibility and adaptation according to project needs

Personlige egenskaper

Hard working, responsible and meticulous individual, with attention to detail and a positive and cooperative attitude

Good communication skills

Experience with project work is an advantage

Vi tilbyr

A stimulating, international and dynamic working environment

Interdisciplinary collaboration within and NoPSC and OUS/UiO

Salary according to qualifications and PhD fellowship standards 

KontaktinformasjonHenrik Rasmussen, Avd. leder, 986 62 323, henrra (at) ous-hf.no
Espen Melum, Lege i spesialisering b, 91780732, espen.melum (at) medisin.uio.no
ArbeidsstedSognsvannsveien 20
0372 Oslo

Søk på stillingen:Klikk her
Nøkkelinformasjon: Arbeidsgiver:Oslo universitetssykehus HF

Referansenr.:4012975048
Stillingsprosent: 100%
Søknadsfrist: 01.03.2019



numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

abstractJV_contact_0: See jobabstractJV_description

contractTypeCodes_0: fulltime

Arbeidsgiver Navn:
The Norwegian PSC Research Center (KIT PSC-forskningssenter)

source: NAV