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Stillingstittel: Postdoctoral researcher - cell/molecular biology;

Stillingsbeskrivelse:

Postdoctoral researcher - cell/molecular biology; functional/computational genomics/bioinformatics

We are seeking a highly motivated and talented individual for working in the fieldof functional epigenomics.
The focus of the group is to study deregulation of chromatin dynamics in cancerpreclinical models and tissue samples to implement new strategies for precisionmedicine. The focus of the project is to identify radiosensitisers to be tested inpreclinical models and understand molecular mechanisms associated with thesetreatment approaches.

Thecandidate is expected to independently conduct research in collaboration withthe project manager, The candidate should be able to take advantage ofpreviously acquired working knowledge of cell and molecular biology techniques andexperience with generating and analyzing transcriptomics and chromatin-relateddata.

The research group of the newly appointed Principal Investigator Dr. Alfonso Urbanucci is embedded within the Department of Tumor Biology at the Institute for Cancer Research, which is a unit of the Oslo University Hospital, located in Montebello close to Radium Hospital and the Oslo Cancer Clusterinnovation park.
Dr Urbanucci's work is in close collaboration with the bioinformatics group ofProf. Eivind Hovig, the urological groups of Prof. Viktor Berge and Prof. Kristin Taskén, and the group of Prof. Gunhild Mælandsmo.

Details on the project and other informal queries are very welcome and should be sentto alfonsourbanucci (at) gmail.com. Applications should be sent though our recruitment portal Webcruiter.

TasksThe ideal candidate will be involved in mice work as well as molecular/biologicalstudies in cell cultures (e.g.: drug and RNAi screenings, CRISPR gene editing),and computational experimental design and analysis of functional genomicsdatasets from next-generation sequencing. Methods to be used includes but are notlimited to ATAC-seq, Hi-C, ChIP-seq, as well as from CRISPR-based approaches. Thecandidate will produce and analyze data, write manuscripts and grant proposals,and will present hi/her work at national and international meetings.
Qualifications

The candidate should have  

• a PhD degree in cell or molecular biology related fields and experience in computational biology or bioinformatics-related field.
• a good understanding of biochemistry, genomics experiments and statistics.
• having worked with prostate cancer models is an advantage.    
  

Personal Characteristics

Demonstrated skills and prior experience in the generation and basics analysis of high-throughput omics datasets is required. The use of R and/or some programming languages is an advantage as well as previous work with mice. Having worked with prostate cancer models is an advantage.
Candidates with proven track record in terms of publications will be given preference.  
Technical Skills (required): 

• Cell culture and RNAi/drug screening 
• Chromatin immunoprecipitation 
• ATAC-seq
• Excellent knowledge of excel, word, endnote, prism, adobe illustrator 
• Good knowledge of Unix and R and understanding of NGS analysis pipelines for chromatin-related data and expression data analysis 
  
  Technical Skills (optional): 
• Nucleic acid and protein extraction from tissue and cells 
• Western blotting 
• qPCR
• Knowledge of some programming language      

We offer

• A position as Post-doctoral research fellow (temporary employment for up to two years), which will be renewed based on performance
• A position in a young, multi-disciplinary and teamwork-oriented Department, which is comprised of both computational andwet-lab scientists.
• Research training and supervision as well as the possibility to supervise students
• An interesting working environment, with the possibility for the right candidate to develop new laboratory skills, and also develop ascomputational biologist in a dry / wet lab environment
• Salary according to qualifications and experience.
  

KontaktinformasjonAlfonso Urbanucci, Scientist
ArbeidsstedUllernchaussen 70
0379 Oslo

Søk på stillingen:Klikk her
Nøkkelinformasjon: Arbeidsgiver:Oslo universitetssykehus HF

Referansenr.:4015896379
Stillingsprosent: 100%
Søknadsfrist: 03/03/2019



numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2131

abstractJV_contact_0: See jobabstractJV_description

contractTypeCodes_0: fulltime

Arbeidsgiver Navn:
Department of Tumor Biology, Institute for Cancer Research

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