Stillingstittel:
PhD positions within the interdisciplinary research project "DrugLogics: Rational development of anti-cancer drug combinations"

Stillingsbeskrivelse:

NTNU - knowledge for a better world

The Norwegian University of Science and Technology (NTNU) creates knowledge for a better world and solutions that can change everyday life.

Faculty of Medicine: Department of Cancer Research and Molecular MedicineFaculty of Natural Sciences and Technology: Department of BiologyFaculty of Humanities: Department of Philosophy and Religious Studies

Jobbnorge ID: 121803

At NTNU, three PhD positions are available, one at each of the departments above, in the NTNU strategic area "NTNU Health". The positions are for a period of three years, starting no later than June 2016.

The Norwegian University of Science and Technology (NTNU) in Trondheim represents academic eminence in technology and the natural sciences as well as in other academic disciplines ranging from the social sciences, the arts, medicine, teacher education, architecture to fine art. Cross-disciplinary cooperation results in innovative breakthroughs and creative solutions with far-reaching social and economic impact.

In 2016 the NTNU Strategic Research Area NTNU Health launches several interdisciplinary projects with relevance to health and health care. The project 'DrugLogics: Rational development of anti-cancer drug combinations' is inspired by a call from NTNU Health, to create innovative solutions to complex health challenges related to Diagnostics and Therapy and is funded under NTNU Health in collaboration with involved faculties.

DrugLogics: Rational development of anti-cancer drug combinationsThe project will build on our established proof of concept for prediction of growth inhibitory effects of combinations of drugs on cancer cells, using computational models of cancer cells that are generated from knowledge in databases and the scientific literature.

The assembly of these models requires the further development of optimised simulation software that is able to make use of the vast but still incomplete systems knowledge available from knowledge bases; we will therefore make extensive use of structured knowledge management to further develop a robust and widely applicable Knowledge Commons for Systems Medicine. Such knowledge management includes practices like literature curation and ontology engineering and we will specifically address technical and social challenges faced while designing and building Knowledge Commons extensions that are optimally suited to enable computational simulations for precise and individuated diagnosis, prevention and treatment of diseases. For this we build on our long standing collaborative research in the area of Philosophy - Systems Medicine - Knowledge Management that crosses over expertise in biomedicine, computation, and science studies at the three NTNU Departments of Cancer Research and Molecular Medicine, Biology and Philosophy and Religious studies. We investigate Responsible Research and Innovation approaches to understand how the Knowledge Commons will transform the innovation systems of medicine and to develop and integrate computational, experimental and analytical approaches for the prediction and validation of the effects of anti-cancer drug combinations on tumours and tumour models.

Our research is embedded in a large international network spanning Europe and the US and will contribute to demonstrate how systems medicine can deliver approaches to predict and validate anti-cancer drug combinatorial treatment both for efficient preclinical screening and for clinical decision support.

A description of the project can be viewed at http://www.DrugLogics-NTNU.org or downloaded at https://www.ntnu.edu/health/druglogics.

Minstelønn: 0

Maksimal lønn: 0

Arbeidsgiver Navn: NTNU - Norges teknisk-naturvitenskapelig

Arbeidsgiver adresse: 7491 TRONDHEIM

Job kort beskrivelse: University and higher education teachers

Land: Norge

Region: Sør-Trøndelag

Kilde til jobbtilbud: NAV, Offentlige arbeidsformidlinger, Norge

Lønn valuta: NOK

Lønn periode: Pr. år